Conantokin-SuB[A8F] (P07411) Protein Card

General Information
Name Conantokin-SuB[A8F] (named by ConoServer)
Alternative name(s) Con-BkB[A8F]
Organism synthetic construct
Protein Type Synthetic
Parent Conantokin-SuB
Notes Conus bocki is renamed as Conus Sulcatus

Classification
Conopeptide class conantokin
Gene superfamily
Pharmacological family

Sequence
GE(Gla)(Gla)YS(Gla)FI(nh2)
Modified residues
positionsymbolname
3GlaGamma carboxylic glutamic acid
4GlaGamma carboxylic glutamic acid
7GlaGamma carboxylic glutamic acid
10nh2C-term amidation
Sequence evidence protein level
Average Mass 1233.16
Monoisotopic Mass 1232.43
Isoelectric Point 1.90
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Ionotropic glutamate receptors

TargetOrganismIC50nhillRef
GluN2AR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)>10 uMPlatt,R.J. et al. (2014)
GluN2BR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)2.1 uM+/-0.6-1Platt,R.J. et al. (2014)
GluN2DR. norvegicus(Expressed in X. laevis oocytes with GluN1-3b subunit.)2.9 uM+/-0.3-1.3Platt,R.J. et al. (2014)

References
Platt,R.J., Curtice,K.J., Twede,V.D., Watkins,M., Gruszczyński,P., Bulaj,G., Horvath,M.P. and Olivera,B.M. (2014) From molecular phylogeny towards differentiating pharmacology for NMDA receptor subtypes. Toxicon 81:67-79

Internal links
Nucleic acids
Structure

External links

Tools