AuIB[F9A] (P07416) Protein Card

General Information
Name AuIB[F9A] (named by ConoServer)
Organism synthetic construct
Protein Type Synthetic
Parent AuIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSYPPCAATNPDC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Sequence evidence protein level
Average Mass 1496.66
Monoisotopic Mass 1495.50
Isoelectric Point 5.47
Extinction Coefficient [280nm] 1490.00

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α3β2R. norvegicus(Adapted from reported "relative current amplitude")16+/-103 uM50 uM AChGrishin,A.A. et al. (2013)
α3β4R. norvegicus(Adapted from reported "relative current amplitude" )0+/-153 uM50 uM AChGrishin,A.A. et al. (2013)
(Adapted from reported "relative current amplitude" )55+/-730 uM50 uM AChGrishin,A.A. et al. (2013)
(Adapted from reported "relative current amplitude")23+/-410 uM50 uM AChGrishin,A.A. et al. (2013)
α4β4R. norvegicus12+/-710 uM50 uM AChGrishin,A.A. et al. (2013)
15+/-1030 uM50 uM AChGrishin,A.A. et al. (2013)
α6β4R. norvegicus(No activity recorded.)03 uM50 uM AChGrishin,A.A. et al. (2013)
α7H. sapiens(Minor potentiation reported. Adapted from reported "relative current amplitude". Error recorded as S)-27+/-43 uM50 uM AChGrishin,A.A. et al. (2013)
0+/-1510 uM50 uM AChGrishin,A.A. et al. (2013)
17+/-3530 uM50 uM AChGrishin,A.A. et al. (2013)
α9α10R. norvegicus41+/-103 uM50 uM AChGrishin,A.A. et al. (2013)

References
Grishin,A.A., Cuny,H., Hung,A., Clark,R.J., Brust,A., Akondi,K., Alewood,P.F., Craik,D.J. and Adams,D.J. (2013) Identifying key amino acid residues that affect α-conotoxin AuIB inhibition of α3β4 nicotinic acetylcholine receptors. J. Biol. Chem. 288:34428-34442

Internal links
Nucleic acids
Structure

External links

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