KIIIA-P2 (P07433) Protein Card

General Information

Name	KIIIA-P2
Organism	synthetic construct
Protein Type	Synthetic
Parent	KIIIA
Notes	Disulfide isomer of KIIIA-P2:[C1-C16,C2-C9,C4-C15]

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	III
Pharmacological family	mu conotoxin

Sequence

CCNCSSKWCRDHSRCC(nh2)
Modified residues	position symbol name 17 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1884.13
Monoisotopic Mass	1882.63
Isoelectric Point	11.73
Extinction Coefficient [280nm]	5500.00

Activity

Kd: Voltage-Gated Sodium Channels

Target	Organism	Kd		Ref
Nav1.2	R. norvegicus	0.23 uM	+/-0.12	Khoo,K.K. et al. (2012)

References

Khoo,K.K., Gupta,K., Green,B.R., Zhang,M.M., Watkins,M., Olivera,B.M., Balaram,P., Yoshikami,D., Bulaj,G. and Norton,R.S. (2012) Distinct disulfide isomers of μ-conotoxins KIIIA and KIIIB block voltage-gated sodium channels. Biochemistry 51:9826-9835

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Monday 27 March 2023