TIA[del1] (P07440) Protein Card

General Information
Name TIA[del1] (named by ConoServer)
Alternative name(s) TIA2–19
Organism synthetic construct
Protein Type Synthetic
Parent TIA
Notes

~89% inhibition of the noradrenergic component of rat vas deferens contraction at 10 uM. (Sharpe et al. 2003)

Dutt et al., 2019 reported that TIA[del1] showed inhibition of zebrafish escape response (IC50 1.34 ± 0.18 μM).


Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family rho conotoxin

Sequence
NWRCCLIPACRRNHKKFC(nh2)
Modified residues
positionsymbolname
19nh2C-term amidation
Sequence evidence protein level
Average Mass 2243.72
Monoisotopic Mass 2242.07
Isoelectric Point 12.82
Extinction Coefficient [280nm] 5500.00

References
Sharpe,I.A., Thomas,L., Loughnan,M., Motin,L., Palant,E., Croker,D.E., Alewood,D., Chen,S., Graham,R.M., Alewood,P.F., Adams,D.J. and Lewis,R.J. (2003) Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA J. Biol. Chem. 278:34451-34457
Dutt, M., Giacomotto, J., Ragnarsson, L., Andersson, Ã…., Brust, A., Dekan, Z., Alewood, P.F. and Lewis, R.J. (2019) The α 1-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa Scientific reports 9:17841

Internal links
Nucleic acids
Structure

External links

Tools