SIIIB[del1] (P07451) Protein Card

General Information
Name SIIIB[del1] (named by ConoServer)
Alternative name(s) SIIIB[2-20]
Organism synthetic construct
Protein Type Synthetic
Parent SIIIB

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
NCCNGGCSSKWCKGHARCC(nh2)
Modified residues
positionsymbolname
20nh2C-term amidation
Sequence evidence protein level
Average Mass 2010.29
Monoisotopic Mass 2008.71
Isoelectric Point 11.98
Extinction Coefficient [280nm] 5500.00

Activity

Ki: Voltage-Gated Sodium Channels

TargetOrganismKiCompetitorAgonistRef
Nav1.2R. norvegicus2.78 nM 125I-TIIIASchroeder,C.I. et al. (2008)
Nav1.4R. norvegicus1.21 nM 125I-TIIIASchroeder,C.I. et al. (2008)

References
Schroeder,C.I., Ekberg,J., Nielsen,K.J., Adams,D., Loughnan,M.L., Thomas,L., Adams,D.J., Alewood,P.F. and Lewis,R.J. (2008) Neuronally mu-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. J. Biol. Chem. 283:21621-21628

Internal links
Nucleic acids
Structure

External links

Tools