RgIA [del13,insC_GAAGG] cyclic (P07469) Protein Card

General Information

Name	RgIA [del13,insC_GAAGG] cyclic (named by ConoServer)
Alternative name(s)	cRgIA-5
Organism	synthetic construct
Protein Type	Synthetic
Parent	RgIA
Notes	Inhibited HVA Ca2+ channel current via GABAB receptors in rat DRG neurons with an IC50 of 11.5 nM. (Halai 2011)

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

GCCSDPRCRYRCGAAGG
Sequence evidence	protein level
Average Mass	1709.90
Monoisotopic Mass	1708.64
Isoelectric Point	12.80
Extinction Coefficient [280nm]	1490.00

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

Target	Organism		% inhibition		Concentration	Ref
α9α10	unidentified	(nAChR was hybrid human α9/rat α10. )	25	+/-5	50 nM	Halai,R. et al. (2011)

References

Halai,R., Callaghan,B., Daly,N.L., Clark,R.J., Adams,D.J. and Craik,D.J. (2011) Effects of cyclization on stability, structure, and activity of α-conotoxin RgIA at the α9α10 nicotinic acetylcholine receptor and GABA(B) receptor. J. Med. Chem. 54:6984-6992

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023