Lt1.3 [globular] (P07480) Protein Card

General Information
Name Lt1.3 [globular]
Organism Conus litteratus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Protein precursor Lt1.3 precursor (7481)

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
GCCSHPACSGNNPYFC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Sequence evidence nucleic acid level
Average Mass 1654.82
Monoisotopic Mass 1653.56
Isoelectric Point 8.42
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α3β2R. norvegicus44.8nM[38.7-51.8]4100uM AchChen J et al. (2018)

Synthetic variants
Lt1.3 [F15A]GCCSHPACSGNNPYAC(nh2)
Lt1.3 [N11A]GCCSHPACSGANPYFC(nh2)
Lt1.3 [N12A]GCCSHPACSGNAPYFC(nh2)
Lt1.3 [P13A]GCCSHPACSGNNAYFC(nh2)
Lt1.3 [S9A]GCCSHPACAGNNPYFC(nh2)
Lt1.3 [Y14A]GCCSHPACSGNNPAFC(nh2)
Lt1.3 [ribbon]GCCSHPACSGNNPYFC(nh2)

References
Chen J, Liang L, Ning H, Cai F, Liu Z, Zhang L, Zhou L, Dai Q (2018) Cloning, Synthesis and Functional Characterization of a Novel α-Conotoxin Lt1.3 Marine drugs 16:112

Internal links
Protein Precursor Lt1.3 precursor (7481)
Nucleic acids
Structure

External links

Tools