GIIIA [A4C,A10C,A20C,A21C] (P07487) Protein Card

General Information
Name GIIIA [A4C,A10C,A20C,A21C] (named by ConoServer)
Alternative name(s) GIIIA-23
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Synthetic
Parent GIIIA

Classification
Conopeptide class conotoxin
Gene superfamily M superfamily
Cysteine framework III
Pharmacological family mu conotoxin

Sequence
RDCATOOKKAKDRQCKOQRAAA(nh2)
Modified residues
positionsymbolname
6O4-Hydroxyproline
7O4-Hydroxyproline
17O4-Hydroxyproline
23nh2C-term amidation
Sequence evidence protein level
Average Mass 2486.86
Monoisotopic Mass 2485.28
Isoelectric Point 11.06
Extinction Coefficient [280nm] 250.00

Activity

IC50: Voltage-Gated Sodium Channels

TargetOrganismIC50Ref
Nav1.4R. norvegicus>100 uMHan et al. (2016)

References
Han, P., Wang, K., Dai, X., Cao, Y., Liu, S., Jiang, H., Fan, C., Wu, W. and Chen, J. (2016) The Role of Individual Disulfide Bonds of μ-Conotoxin GIIIA in the Inhibition of Nav1. 4 Marine drugs 14:213

Internal links
Nucleic acids
Structure

External links

Tools