EIIB (P07538) Protein Card

General Information

Name	EIIB
Organism	Conus ermineus (Atlantic fish-hunting cone)
Organism region	Eastern Atlantic and Mediterranean,Western Atlantic and Caribbean
Organism diet	piscivorous
Protein Type	Wild type

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

ZTOGCCWHPACGKNRC(nh2)
Modified residues	position symbol name 1 Z Pyroglutamic acid 3 O 4-Hydroxyproline 17 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1754.99
Monoisotopic Mass	1753.67
Isoelectric Point	NA
Extinction Coefficient [280nm]	NA

Activity

Ki: Nicotinic acetylcholine receptors

Target	Organism	Ki		Competitor	Agonist	Ref
α1β1γδ	T. marmorata	2.2nM	+/-0.7	BgTx		Echterbille,J. et al. (2017)

References

Echterbille,J., Gilles,N., Araóz,R., Mourier,G., Amar,M., Servent,D., De Pauw,E. and Quinton,L. (2017) Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon 130:1-10

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Wednesday 22 March 2023