EIIB (P07538) Protein Card

General Information
Name EIIB
Organism Conus ermineus (Atlantic fish-hunting cone)
Organism region Western Atlantic and Caribbean,Eastern Atlantic and Mediterranean
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
ZTOGCCWHPACGKNRC(nh2)
Modified residues
positionsymbolname
1ZPyroglutamic acid
3O4-Hydroxyproline
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1754.99
Monoisotopic Mass 1753.67
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

Ki: Nicotinic acetylcholine receptors

TargetOrganismKiCompetitorAgonistRef
α1β1γδT. marmorata2.2nM+/-0.7BgTxEchterbille,J. et al. (2017)

References
Echterbille,J., Gilles,N., Araóz,R., Mourier,G., Amar,M., Servent,D., De Pauw,E. and Quinton,L. (2017) Discovery and characterization of EIIB, a new α-conotoxin from Conus ermineus venom by nAChRs affinity capture monitored by MALDI-TOF/TOF mass spectrometry. Toxicon 130:1-10

Internal links
Nucleic acids
Structure

External links

Tools