GID [(Gla)4E, A10T] (P07545) Protein Card

General Information
Name GID [(Gla)4E, A10T] (named by ConoServer)
Organism synthetic construct
Protein Type Synthetic
Parent GID

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
IRDECCSNPTCRVNNOHVC
Modified residues
positionsymbolname
16O4-Hydroxyproline
Sequence evidence protein level
Average Mass 2172.40
Monoisotopic Mass 2170.88
Isoelectric Point 8.31
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α3β2R. norvegicus>100uM100nM epibatidineBanerjee,J. et al. (2014)
α4β2R. norvegicus>100uM100nM epibatidineBanerjee,J. et al. (2014)

References
Banerjee,J., Yongye,A.B., Chang,Y.P., Gyanda,R., Medina-Franco,J.L. and Armishaw,C.J. (2014) Design and synthesis of alpha-conotoxin GID analogues as selective alpha4beta2 nicotinic acetylcholine receptor antagonists. Biopolymers 102:78-87

Internal links
Nucleic acids
Structure

External links

Tools