GID [(Gla)4E, V13I] (P07549) Protein Card

General Information

Name	GID [(Gla)4E, V13I] (named by ConoServer)
Organism	synthetic construct
Protein Type	Synthetic
Parent	GID

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

IRDECCSNPACRINNOHVC

Modified residues

position	symbol	name
16	O	4-Hydroxyproline

Sequence evidence

protein level

Average Mass

2156.41

Monoisotopic Mass

2154.88

Isoelectric Point

8.31

Extinction Coefficient [280nm]

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α3β2	R. norvegicus	0.13uM	+/-0.041	100nM epibatidine	Banerjee,J. et al. (2014)
α4β2	R. norvegicus	6.0uM	+/-1.3	100nM epibatidine	Banerjee,J. et al. (2014)

References

Banerjee,J., Yongye,A.B., Chang,Y.P., Gyanda,R., Medina-Franco,J.L. and Armishaw,C.J. (2014) Design and synthesis of alpha-conotoxin GID analogues as selective alpha4beta2 nicotinic acetylcholine receptor antagonists. Biopolymers 102:78-87

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 28 March 2023