conantokin-Rl2[O10P] (P07642) Protein Card

General Information

Name	conantokin-Rl2[O10P] (named by ConoServer)
Alternative name(s)	conRl-B[O10P]
Organism	synthetic construct
Protein Type	Synthetic
Parent	Conantokin-Rl2

Classification

Conopeptide class	conantokin
Gene superfamily
Pharmacological family

Sequence

GE(Gla)(Gla)LA(Gla)KAP(Gla)FAR(Gla)LAN(nh2)
Modified residues	position symbol name 3 Gla Gamma carboxylic glutamic acid 4 Gla Gamma carboxylic glutamic acid 7 Gla Gamma carboxylic glutamic acid 11 Gla Gamma carboxylic glutamic acid 15 Gla Gamma carboxylic glutamic acid 19 nh2 C-term amidation
Average Mass	2222.22
Monoisotopic Mass	2220.93
Isoelectric Point	2.02
Extinction Coefficient [280nm]	NA

References

Yuan,Y., Balsara,R.D., Zajicek,J., Kunda,S. and Castellino,F.J. (2016) Discerning the Role of the Hydroxyproline Residue in the Structure of Conantokin Rl-B and Its Role in GluN2B Subunit-Selective Antagonistic Activity toward N-Methyl-d-Aspartate Receptors. Biochemistry 55:7112-7122

Internal links

Nucleic acids
Structure	The Solution Structure of the Magnesium-bound Conantokin-R1B [O10P]

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 5 December 2023