Vc1.1 [D11E,E14A,insC_GGAAGG] cyclic (P07645) Protein Card

General Information
Name Vc1.1 [D11E,E14A,insC_GGAAGG] cyclic (named by ConoServer)
Organism synthetic construct
Protein Type Synthetic
Parent Vc1.1
Notes Vc1.1 [D11E,E14A,ins_GGAAGG] cyclic inhibited HVA calcium channel current amplitude by 48.9 ± 4.7% (n = 7) at 100 nM.

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSDPRCNYEHPAICGGAAGG
Sequence evidence protein level
Average Mass 2116.29
Monoisotopic Mass 2114.78
Isoelectric Point 6.62
Extinction Coefficient [280nm] 1490.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α9α10H. sapiens29.3 μM+/-3Ach (1 uM)Sadeghi M et al. (2018)
R. norvegicus17.9 μM+/-2.6Ach (1 uM)Sadeghi M et al. (2018)

References
Sadeghi M, Carstens BB, Callaghan BP, Daniel JT, Tae HS, O Donnell T, Castro J, Brierley SM, Adams DJ, Craik DJ, Clark RJ (2018) Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1. ACS Chem. Biol. 13:1577-1587

Internal links
Nucleic acids
Structure Backbone cyclised conotoxin Vc1.1 mutant - D11A, E14A

External links

Tools