VnIB (P07652) Protein Card

General Information

Name	VnIB
Organism	Conus ventricosus
Organism region	Eastern Atlantic and Mediterranean
Organism diet	vermivorous
Protein Type	Wild type
Protein precursor	VnIB precursor (7653)

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family	alpha conotoxin

Sequence

GGCCSHPVCYTKNPNCG
Sequence evidence	nucleic acid level
Average Mass	1735.93
Monoisotopic Mass	1734.64
Isoelectric Point	10.45
Extinction Coefficient [280nm]	1490.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		nhill	Ref
α1β1δε	H. sapiens	>10 uM			Van Hout et al. (2019)
α2β2	R. norvegicus	>10 uM			Van Hout et al. (2019)
α2β4	R. norvegicus	>10 uM			Van Hout et al. (2019)
α3β2	R. norvegicus	>10 uM			Van Hout et al. (2019)
α3β4	H. sapiens	>10 uM			Van Hout et al. (2019)
	R. norvegicus	320nM	[250-390]	1.2	Van Hout et al. (2019)
α4β2	H. sapiens	>10 uM			Van Hout et al. (2019)
	R. norvegicus	>10 uM			Van Hout et al. (2019)
α4β4	R. norvegicus	>10 uM			Van Hout et al. (2019)
α6β4	R. norvegicus	12nM	[9.9-15]	1.2	Van Hout et al. (2019)
α6/α3β2β3	H. sapiens	>10 uM			Van Hout et al. (2019)
	R. norvegicus	4000nM	[2500-6900]	0.53	Van Hout et al. (2019)
α6/α3β4	H. sapiens	5.3nM	[4.1-6.9]	1.1	Van Hout et al. (2019)
	R. norvegicus	18nM	[16-20]	1.1	Van Hout et al. (2019)
α7	R. norvegicus	>10 uM			Van Hout et al. (2019)
α9α10	R. norvegicus	>10 uM			Van Hout et al. (2019)

Ki: Nicotinic acetylcholine receptors

Target	Organism	Ki		Competitor	Agonist	Ref
α6β4	R. norvegicus	11.7nM	+/-5.01			Van Hout et al. (2019)

References

Van Hout, M., Valdes, A., Christensen, S.B., Tran, P.T., Watkins, M., Gajewiak, J., Jensen, A.A., Olivera, B.M. and McIntosh, J.M. (2019) α-Conotoxin VnIB from Conus ventricosus is a potent and selective antagonist of α6β4* nicotinic acetylcholine receptors Neuropharmacology 157:107691

Internal links

Protein Precursor	VnIB precursor (7653)
Nucleic acids
Structure

External links

Ncbi

MK120500

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 28 May 2023