Cal29b precursor (P07851) Protein Card

General Information

Name	Cal29b precursor (named by ConoServer)
Alternative name(s)	O1_cal29b precursor
Organism	Conus californicus
Organism region	Eastern Pacific
Organism diet	piscivorous
Protein Type	Precursor
Notes	O1_cal29b was tested on a pathogen reference strain (H37Rv) and multidrug-resistant strains, having an inhibition effect on growth with a minimal inhibitory concentration (MIC)range of 3.52–0.22 M,similar concentrations to drugs used in clinics.

Classification

Conopeptide class	conotoxin
Gene superfamily	O1 superfamily
Cysteine framework	XXIX
Pharmacological family

Sequence

MKLTCVLIVAVLILAACQFTAA NMARYGKTQIARSDVKSID AR RPKCCCVCGVVGRKCCSTWKDCHPVHLPCPSSG
Sequence evidence	protein level
Sequence region	[1-22] signal sequence [23-43] pro region [44-76] mature peptide Cal29b

References

Bernáldez-Sarabia,J., Figueroa-Montiel,A., Dueñas,S., Cervantes-Luévano,K., Beltrán,J.A., Ortiz,E., Jiménez,S., Possani,L.D., Paniagua-Solís,J.F., Gonzalez-Canudas,J., and Licea-Navarro,A. (2019) The Diversified O-Superfamily in Californiconus californicus Presents a Conotoxin with Antimycobacterial Activity Toxins 11:128

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 26 March 2023