Con-Ins K1 precursor (P07889) Protein Card

General Information
Name Con-Ins K1 precursor
Organism Conus kinoshitai
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor
Notes Con-Ins K1 is potent at the hIR-B with an EC50 of 30.45 nM. Consistent with hIR-B binding and activation data, Con-Ins K1 was less effective at lowering blood glucose at 10-times the concen-tration of human insulin (Figure 5D). When tested at 20-times (equivalent to 20 IU/kg body weight) Con-Ins K1 showed a similar in vivo effect to human insulin.

Classification
Conopeptide class coninsulin
Gene superfamily Insulin superfamily
Pharmacological family

Sequence
MTTSSYFLLVALGLLLYVCQSSFG
SPHT
SDSGTTLVRRRLC
GSELVTYLGELCLGN
RKRRGFPSMLKARAKRNEAFLLQRDG
R
GIVEDCCYNDCTDEKLKEYCHTLQ
G
Sequence evidence nucleic acid level
Sequence region
[1-24]signal sequence
[29-56]mature peptideCon-Ins K1 B Chain
[84-107]mature peptideCon-Ins K1 A Chain

References
Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E. (2019) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife 8

Internal links
Nucleic acids Con-Ins K1 precursor
Structure

External links
Ncbi MH879033

Tools