Con-Ins K2 precursor (P07890) Protein Card

General Information
Name Con-Ins K2 precursor
Organism Conus kinoshitai
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor
Notes Con-Ins K2 bound to the hIR with affinity at IC50 275.2 nM (162.2–487.6 nM; 95 % CI), and it is potent at the hIR-B with an 373.2 nM (95 % CI 61.6–2262.0 nM).

Classification
Conopeptide class coninsulin
Gene superfamily Insulin superfamily
Pharmacological family

Sequence
MTTSSYFLLVALGLLLYVCQSSFG
NPHTRD
SGTTPDRDHSC
GGELVDRLVKLCPSN
RKRRGFPSMLKARAKRNEAFLLQRDG
R
VIVGDCCDNYCTDERLKGYCASLLGL
Sequence evidence nucleic acid level
Sequence region
[1-24]signal sequence
[31-56]mature peptideCon-Ins K2 B Chain
[84-109]mature peptideCon-Ins K2 A Chain

References
Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E. (2019) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife 8

Internal links
Nucleic acids
Structure

External links
Ncbi MH87903

Tools