Con-Ins T1A precursor (P07891) Protein Card

General Information
Name Con-Ins T1A precursor
Organism Conus tulipa (tulip cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor
Notes Administration of venom insulins at 65 ng peptide/g body weight significantly lowered blood glucose levels for Con-Ins T1A (p<0.0001, n = 5) at 77.8 ± 39.8 mg/dL. Con-Ins T1A bounds to the hIR with an affinity at IC50 9.92 nM (7.75–12.68 nM; 95% CI), and was potently active at the hIR-B at EC50 12.0, 95% CI: 9.7–15.0 nM.

Classification
Conopeptide class coninsulin
Gene superfamily Insulin superfamily
Pharmacological family

Sequence
MTTSFYFLLMALGLLLYVCQS
SFGNQHTR
NSDTPKYRCGSE
IPNSYIDLCF
RKRNDAGKKRGRASPLWQRGGSLSMLKARAK
RNEAFHLQRAHR
GVVEHCCHRPCSNAEFKKFC
G
Sequence evidence nucleic acid level
Sequence region
[1-21]signal sequence
[30-51]mature peptideCon-Ins T1A B Chain
[95-114]mature peptideCon-Ins T1A A Chain

References
Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E. (2019) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife 8

Internal links
Nucleic acids Con-Ins T1A precursor
Structure

External links
Ncbi KP268600

Tools