Con-Ins T1B precursor (P07892) Protein Card

General Information

Name	Con-Ins T1B precursor
Organism	Conus tulipa (tulip cone)
Organism region	Indo-Pacific
Organism diet	piscivorous
Protein Type	Precursor
Notes	Con-Ins T1B was potently active at the hIR-B at EC50 of 12.0 nM, 95% CI: 10.2–13.8 nM.

Classification

Conopeptide class	coninsulin
Gene superfamily	Insulin superfamily
Pharmacological family

Sequence

MTTSFYFLLMALGLLLYVCQS SFGNQHTR NSDTPKYRCGSD IPNSYMDLCF RKRNDAGKKRGQASPLWQRGGSLSMLKARAK RNEAFHLQRAHR GVVEHCCYRPCSNAEFKKFC G
Sequence evidence	nucleic acid level
Sequence region	[1-21] signal sequence [30-51] mature peptide Con-Ins T1B B Chain [95-114] mature peptide Con-Ins T1B A Chain

References

Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E. (2019) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife 8

Internal links

Nucleic acids	Con-Ins T1B precursor
Structure

External links

Ncbi

KP268611

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 28 March 2023