Con-Ins T1B precursor (P07892) Protein Card

General Information
Name Con-Ins T1B precursor
Organism Conus tulipa (tulip cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor
Notes Con-Ins T1B was potently active at the hIR-B at EC50 of 12.0 nM, 95% CI: 10.2–13.8 nM.

Classification
Conopeptide class coninsulin
Gene superfamily Insulin superfamily
Pharmacological family

Sequence
MTTSFYFLLMALGLLLYVCQS
SFGNQHTR
NSDTPKYRCGSD
IPNSYMDLCF
RKRNDAGKKRGQASPLWQRGGSLSMLKARAK
RNEAFHLQRAHR
GVVEHCCYRPCSNAEFKKFC
G
Sequence evidence nucleic acid level
Sequence region
[1-21]signal sequence
[30-51]mature peptideCon-Ins T1B B Chain
[95-114]mature peptideCon-Ins T1B A Chain

References
Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E. (2019) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife 8

Internal links
Nucleic acids Con-Ins T1B precursor
Structure

External links
Ncbi KP268611

Tools