Con-Ins G1 precursor (P07893) Protein Card

General Information
Name Con-Ins G1 precursor
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor
Notes Con-Ins G1 potently activates the human insulins receptor, albeit at lower potency when compared to human insulin (EC50 of Con-Ins G1 16.28 nM; 95% CI: 7.3–36.4 nM; EC50 of human insulin 1.5 nM; 95% CI: 1.1–2.1 nM, in which the EC50 indicates half-maximal effective concentration)

Classification
Conopeptide class coninsulin
Gene superfamily Insulin superfamily
Pharmacological family

Sequence
MTTSSYFLLMALGLLLYVCQS
SFGNQHTR
TFDTPKHRCGSE
ITNSYMDLCY
RKRNDAGEKRGRASPLWQRRGSLSKLKARAK
RNGAFHLPRDGR
GVVEHCCHRPCSNAEFKKYC
G
Sequence evidence nucleic acid level
Sequence region
[1-21]signal sequence
[30-51]mature peptideCon-Ins G1 B Chain
[95-114]mature peptideCon-Ins G1 A Chain

References
Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E. (2019) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife 8

Internal links
Nucleic acids
Structure

External links
Ncbi AJD85832

Tools