Con-Ins G3 precursor (P07894) Protein Card

General Information
Name Con-Ins G3 precursor
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor
Notes Con-Ins G3 was significantly less potent at the hIR-B with an EC50 of 242.0 nM, 95% CI: 101.3–578.5 nM.

Classification
Conopeptide class coninsulin
Gene superfamily Insulin superfamily
Pharmacological family

Sequence
MTTSFYFLLVALGLLLYVCQS
SFGNQHTR
NSDTPKHRCGSE
LADQYVQLCH
GKRNDAGKKRGRASPLWQRQGFLSMLKAKRN
EAFFLQRDGR
GIVEVCCDNPCTVATLRTFCH
Sequence evidence nucleic acid level
Sequence region
[1-21]signal sequence
[30-51]mature peptideCon-Ins G3 B Chain
[93-113]mature peptideCon-Ins G3 A Chain

References
Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E. (2019) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife 8

Internal links
Nucleic acids
Structure

External links
Ncbi AJD85820

Tools