Con-Ins T2 precursor (P07895) Protein Card

General Information
Name Con-Ins T2 precursor
Organism Conus tulipa (tulip cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor
Notes Administration of venom insulins at 65 ng peptide/g body weight significantly lowered blood glucose levels for Con-Ins T2 with values 199.2 ± 39.8 mg/dL (p<0.0067, n = 5). Con-Ins T2 was potently active at the hIR-B EC50 15.5 nM, 95% CI: 11.9–20.2 nM)

Classification
Conopeptide class coninsulin
Gene superfamily Insulin superfamily
Pharmacological family

Sequence
MTTSFYFLLVALGLLLYVCQS
SFGNQHTR
NSDTPWNRCGSQ
ITDSYRELCPH
KRNDAGKKRGQASPLWQRGGSLSMLKARAK
RNEAFHLQRAHR
GVVEHCCKRACSNAEFMQFC
G
Sequence evidence nucleic acid level
Sequence region
[1-21]signal sequence
[30-52]mature peptideCon-Ins T2 B Chain
[95-114]mature peptideCon-Ins T2 A Chain

References
Ahorukomeye, P., Disotuar, M.M., Gajewiak, J., Karanth, S., Watkins, M., Robinson, S.D., Salcedo, P.F., Smith, N.A., Smith, B.J., Schlegel, A. and Forbes, B.E. (2019) Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor eLife 8

Internal links
Nucleic acids Con-Ins T2 precursor
Structure

External links
Ncbi MH879035

Tools