BuIA[G1K,del2,C8S] (P07919) Protein Card

General Information

Name	BuIA[G1K,del2,C8S] (named by ConoServer)
Alternative name(s)	cotx 2.13
Organism	synthetic construct
Protein Type	Synthetic
Parent	BuIA
Notes	Liu et al. 2019 reported affinities as being EC50s but the method used in that study is microscale-thermophoresis (MST)technology, which is used to calculate Ki.

Classification

Conopeptide class	conotoxin
Gene superfamily
Pharmacological family	alpha conotoxin

Sequence

KCSTPPDAVLYC
Average Mass	1294.50
Monoisotopic Mass	1293.57
Isoelectric Point	7.77
Extinction Coefficient [280nm]	1490.00

Activity

Ki: Nicotinic acetylcholine receptors

Target	Organism	Ki		Competitor	Agonist	Ref
α7	R. norvegicus	15.4 nM	+/-1.6			Liu et al. (2019)

References

Liu, C., Wu, P., Zhu, H., Grieco, P., Yu, R., Gao, X., Wu, G., Wang, D., Xu, H. and Qi, W. (2019) Rationally Designed α-Conotoxin Analogues Maintained Analgesia Activity and Weakened Side Effects Molecules 24:337

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 28 March 2023