MII precursor (P00008) Protein Card

General Information
Name MII precursor
Organism Conus magus (Magus cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Pharmacological family

Sequence
MGMRMMFTVFLLVVLATTVVS
FPSDRASDGRNAAANDKASD
VITLALK
GCCSNPVCHLEHSNLC
GRRR
Sequence region
[1-21]signal sequence
[49-64]mature peptideMII

References
Santos,A.D., McIntosh,J.M., Hillyard,D.R., Cruz,L.J. and Olivera,B.M. (2004) The A-superfamily of conotoxins: structural and functional divergence J. Biol. Chem. 279:17596-17606
McIntosh,J.M., Dowell,C., Watkins,M., Garrett,J.E., Yoshikami,D. and Olivera,B.M. (2002) Alpha-conotoxin GIC from Conus geographus, a novel peptide antagonist of nicotinic acetylcholine receptors J. Biol. Chem. 277:33610-33615
Cartier,G.E., Yoshikami,D., Gray,W.R., Luo,S., Olivera,B.M. and McIntosh,J.M. (1996) A new alpha-conotoxin which targets alpha3beta2 nicotinic acetylcholine receptors J. Biol. Chem. 271:7522-7528
Kuryatov,A., Olale,F., Cooper,J., Choi,C. and Lindstrom,J. (2000) Human alpha6 AChR subtypes: subunit composition, assembly, and pharmacological responses Neuropharmacology 39:2570-2590
Shon,K.J., Koerber,S.C., Rivier,J.E., Olivera,B.M. and McIntosh,J.M. (1997) Three-dimensional solution structure of alpha-conotoxin MII, an alpha3beta2 neuronal nicotinic acetylcholine receptor-targeted ligand Biochemistry 36:15693-15700
Hill,J.M., Oomen,C.J., Miranda,L.P., Bingham,J.P., Alewood,P.F. and Craik,D.J. (1998) Three-dimensional solution structure of alpha-conotoxin MII by NMR spectroscopy: effects of solution environment on helicity Biochemistry 37:15621-15630
Clark,R.J., Fischer,H., Dempster,L., Daly,N.L., Rosengren,K.J., Nevin,S.T., Meunier,F.A., Adams,D.J. and Craik,D.J. (2005) Engineering stable peptide toxins by means of backbone cyclization: stabilization of the alpha-conotoxin MII Proc. Natl. Acad. Sci. U.S.A. 102:13767-13772
Everhart,D., Cartier,G.E., Malhotra,A., Gomes,A.V., McIntosh,J.M. and Luetje,C.W. (2004) Determinants of potency on alpha-conotoxin MII, a peptide antagonist of neuronal nicotinic receptors Biochemistry 43:2732-2737

Internal links
Nucleic acids Alpha-conotoxin peptides
Structure

External links
UniProtKB/Swiss-Prot P56636
Ncbi P56636

Tools