CIA (P08016) Protein Card

General Information
Name CIA
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor CIA precursor (8497)
Notes Giribaldi J., et al reported that CIA is inactivity on the α7 and α4β2 subtypes at concentrations up to 10 μM.

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Sequence
NGRCCHPACGKHFSC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Sequence evidence protein level
Average Mass 1618.88
Monoisotopic Mass 1617.65
Isoelectric Point 8.48
Extinction Coefficient [280nm] 500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδR. norvegicus5.7 nM100 uMGiribaldi et al. (2018)
α3β2R. norvegicus2.06 uM100 uMGiribaldi et al. (2018)

References
Giribaldi, J., Wilson, D., Nicke, A., El Hamdaoui, Y., Laconde, G., Faucherre, A., Moha Ou Maati, H., Daly, N., Enjalbal, C. and Dutertre, S. (2018) Synthesis, structure and biological activity of CIA and CIB, two α-conotoxins from the predation-evoked venom of Conus catus Toxins 10:222

Internal links
Protein Precursor CIA precursor (8497)
Nucleic acids
Structure

External links
UniProtKB/Swiss-Prot D4HPD6

Tools