CIB (P08017) Protein Card

General Information
Name CIB
Alternative name(s) Ca003
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Notes Giribaldi J., et al reported that CIB is inactivity on the muscle and α4β2 subtypes at concentrations up to 10 μM.

Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family alpha conotoxin

Modified residues
17nh2C-term amidation
Sequence evidence protein level
Average Mass 1678.89
Monoisotopic Mass 1677.63
Isoelectric Point 6.81
Extinction Coefficient [280nm] 500.00


IC50: Nicotinic acetylcholine receptors

α3β2R. norvegicus128.9 uM100 uMGiribaldi et al. (2018)
α7R. norvegicus 1.51 uM100 uMGiribaldi et al. (2018)

Giribaldi, J., Wilson, D., Nicke, A., El Hamdaoui, Y., Laconde, G., Faucherre, A., Moha Ou Maati, H., Daly, N., Enjalbal, C. and Dutertre, S. (2018) Synthesis, structure and biological activity of CIA and CIB, two α-conotoxins from the predation-evoked venom of Conus catus Toxins 10:222
Himaya, S.W.A., Jin, A.H., Dutertre, S., Giacomotto, J., Mohialdeen, H., Vetter, I., Alewood, P.F. and Lewis, R.J. (2015) Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus. Journal of proteome research 14:4372-4381

Internal links
Nucleic acids

External links
UniProtKB/Swiss-Prot P0DPT2