GVIA precursor (P00820) Protein Card

General Information
Name GVIA precursor
Organism Conus geographus (Geography cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor

Conopeptide class conotoxin
Gene superfamily O1 superfamily
Pharmacological family

Sequence region
[1-22]signal sequence
[46-72]mature peptideGVIA

Colledge,C.J., Hunsperger,J.P., Imperial,J.S. and Hillyard,D.R. (1992) Precursor structure of omega-conotoxin GVIA determined from a cDNA clone Toxicon 30:1111-1116
Olivera,B.M., McIntosh,J.M., Cruz,L.J., Luque,F.A. and Gray,W.R. (1984) Purification and sequence of a presynaptic peptide toxin from Conus geographus venom Biochemistry 23:5087-5090
Olivera,B.M., Gray,W.R., Zeikus,R., McIntosh,J.M., Varga,J., Rivier,J., de Santos,V. and Cruz,L.J. (1985) Peptide neurotoxins from fish-hunting cone snails Science 230:1338-1343
Nishiuchi,Y., Kumagaye,K., Noda,Y., Watanabe,T.X. and Sakakibara,S. (1986) Synthesis and secondary-structure determination of omega-conotoxin GVIA: a 27-peptide with three intramolecular disulfide bonds Biopolymers 25 Suppl
Sato,K., Park,N.G., Kohno,T., Maeda,T., Kim,J.I., Kato,R. and Takahashi,M. (1993) Role of basic residues for the binding of omega-conotoxin GVIA to N-type calcium channels Biochem. Biophys. Res. Commun. 194:1292-1296
Kim,J.I., Takahashi,M., Ogura,A., Kohno,T., Kudo,Y. and Sato,K. (1994) Hydroxyl group of Tyr13 is essential for the activity of omega-conotoxin GVIA, a peptide toxin for N-type calcium channel J. Biol. Chem. 269:23876-23878
Lew,M.J., Flinn,J.P., Pallaghy,P.K., Murphy,R., Whorlow,S.L., Wright,C.E., Norton,R.S. and Angus,J.A. (1997) Structure-function relationships of omega-conotoxin GVIA. Synthesis, structure, calcium channel binding, and functional assay of alanine-substituted analogues J. Biol. Chem. 272:12014-12023
Sevilla,P., Bruix,M., Santoro,J., Gago,F., Garcia,A.G. and Rico,M. (1993) Three-dimensional structure of omega-conotoxin GVIA determined by 1H NMR Biochem. Biophys. Res. Commun. 192:1238-1244
Davis,J.H., Bradley,E.K., Miljanich,G.P., Nadasdi,L., Ramachandran,J. and Basus,V.J. (1993) Solution structure of omega-conotoxin GVIA using 2-D NMR spectroscopy and relaxation matrix analysis Biochemistry 32:7396-7405
Pallaghy,P.K., Duggan,B.M., Pennington,M.W. and Norton,R.S. (1993) Three-dimensional structure in solution of the calcium channel blocker omega-conotoxin J. Mol. Biol. 234:405-420
Skalicky,J.J., Metzler,W.J., Ciesla,D.J., Galdes,A. and Pardi,A. (1993) Solution structure of the calcium channel antagonist omega-conotoxin GVIA Protein Sci. 2:1591-1603
Pallaghy,P.K. and Norton,R.S. (1999) Refined solution structure of omega-conotoxin GVIA: implications for calcium channel binding J. Pept. Res. 53:343-351
Nielsen,K.J., Schroeder,T. and Lewis,R. (2000) Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels J. Mol. Recognit. 13:55-70

Internal links
Nucleic acids Conus geographus omega-conotoxin precursor GVIA mRNA, complete cds

External links
UniProtKB/Swiss-Prot P01522
Ncbi AAA81590, P01522