TxID[S9(Abu)] (P08418) Protein Card

General Information

Name	TxID[S9(Abu)]
Organism	synthetic construct
Protein Type	Synthetic
Parent	TxID

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	I
Pharmacological family

Sequence

GCCSHPVC(Abu)AMSPIC(nh2)
Modified residues	position symbol name 9 Abu alpha-aminobutyric acid 16 nh2 C-term amidation
Average Mass	1487.80
Monoisotopic Mass	1486.56
Isoelectric Point	8.31
Extinction Coefficient [280nm]	500.00

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		nhill	Agonist	Ref
α3β4	R. norvegicus	1.9 nM	[1.5-2.5]	1.3	Ach (100 uM)	Yu et al. (2018)
α6/α3β4	R. norvegicus	6.2 nM	[4.6-8.4]	1.3	Ach (100 uM)	Yu et al. (2018)

References

Yu, J., Zhu, X., Harvey, P.J., Kaas, Q., Zhangsun, D., Craik, D.J. and Luo, S. (2018) Single Amino Acid Substitution in α-Conotoxin TxID Reveals a Specific α3β4 Nicotinic Acetylcholine Receptor Antagonist Journal of medicinal chemistry 61:9256-9265

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Thursday 1 June 2023