AuIB [N12A,ribbon] (P08448) Protein Card

General Information
Name AuIB [N12A,ribbon] (named by ConoServer)
Organism synthetic construct
Protein Type Synthetic
Parent AuIB [ribbon]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family

Sequence
GCCSYPPCFATAPDC(nh2)
Modified residues
positionsymbolname
16nh2C-term amidation
Sequence evidence protein level
Average Mass 1529.73
Monoisotopic Mass 1528.52
Isoelectric Point 5.47
Extinction Coefficient [280nm] 1490.00

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α3β4R. norvegicus401 μMWu et al. (2018)
40100 μMWu et al. (2018)

References
Wu, X., Tae, H.S., Huang, Y.H., Adams, D.J., Craik, D.J. and Kaas, Q. (2018) Stoichiometry dependent inhibition of rat α3β4 nicotinic acetylcholine receptor by the ribbon isomer of α-conotoxin AuIB Biochemical pharmacology 155:288-297

Internal links
Nucleic acids
Structure

External links

Tools