RegIIA[H5D] (P08487) Protein Card

General Information
Name RegIIA[H5D]
Organism synthetic construct
Protein Type Synthetic
Parent RegIIA

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework I
Pharmacological family

Sequence
GCCSDPACNVNNPHIC(nh2)
Modified residues
positionsymbolname
17nh2C-term amidation
Average Mass 1641.82
Monoisotopic Mass 1640.59
Isoelectric Point 5.63
Extinction Coefficient [280nm] NA

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50nhillAgonistRef
α7H. sapiens13680 nM[7370-25400]0.6 200 uM AchYu et al. (2018)
R. norvegicus100 nM[79-140]1.1200 uM AchYu et al. (2018)

References
Yu, J., Zhu, X., Zhang, L., Kudryavtsev, D., Kasheverov, I., Lei, Y., Zhangsun, D., Tsetlin, V. and Luo, S. (2018) Species specificity of rat and human α7 nicotinic acetylcholine receptors towards different classes of peptide and protein antagonists Neuropharmacology 139:226-237

Internal links
Nucleic acids
Structure

External links

Tools