CIC (P08508) Protein Card

General Information
Name CIC (named by ConoServer)
Alternative name(s) C1.1,Ca001
Organism Conus catus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type

Classification
Conopeptide class conotoxin
Gene superfamily A superfamily
Cysteine framework I
Pharmacological family

Sequence
ASGADTCCSNPACQVQHSDLC
Sequence evidence nucleic acid level
Average Mass 2106.25
Monoisotopic Mass 2104.77
Isoelectric Point 4.50
Extinction Coefficient [280nm] 500.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1γδR. norvegicus>10 µM100 μM AChGiribaldi,J. et al. (2021)
α2β2R. norvegicus>10 µM100 μM AChGiribaldi,J. et al. (2021)
α2β4R. norvegicus>10 µM100 μM AChGiribaldi,J. et al. (2021)
α3β2R. norvegicus3.51 µM100 μM AChGiribaldi,J. et al. (2021)
α3β4R. norvegicus>10 µM100 μM AChGiribaldi,J. et al. (2021)
α4β2R. norvegicus>10 µM100 μM AChGiribaldi,J. et al. (2021)
α4β4R. norvegicus>10 µM100 μM AChGiribaldi,J. et al. (2021)
α6/α3β2β3R. norvegicus1.03 µM100 μM AChGiribaldi,J. et al. (2021)
α7R. norvegicus>10 µM100 μM AChGiribaldi,J. et al. (2021)
α9α10H. sapiens>10 µM100 μM AChGiribaldi,J. et al. (2021)

Synthetic variants
CIC[del1-6]CCSNPACQVQHSDLC

References
Himaya, S.W.A., Jin, A.H., Dutertre, S., Giacomotto, J., Mohialdeen, H., Vetter, I., Alewood, P.F. and Lewis, R.J. (2015) Comparative venomics reveals the complex prey capture strategy of the piscivorous cone snail Conus catus. Journal of proteome research 14:4372-4381
Giribaldi,J., Haufe,Y., Evans,E.R.J., Wilson,D.T., Daly,N.L., Enjalbal,C., Nicke,A. and Dutertre,S. (2021) Synthesis, Structural and Pharmacological Characterizations of CIC, a Novel α-Conotoxin with an Extended N-Terminal Tail. Mar Drugs 19

Internal links
Nucleic acids
Structure

External links

Tools