SO3 precursor (P00864) Protein Card

General Information
Name SO3 precursor
Organism Conus striatus (Striated cone)
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Precursor
Notes The mature peptide region is from Lu BS et al. 1999 and differs from the Swiss-Prot card.

Classification
Conopeptide class conotoxin
Gene superfamily O1 superfamily
Pharmacological family

Sequence
MKLTCMVIVAVLLLTACQLITA
DDSRGTQKHRTLRSKTKLS
MSTR
CKAAGKPCSRIAYNCCTGSCRSGKC
G
Sequence region
[1-22]signal sequence
[46-70]mature peptideSO3

References
Lu,B.S., Yu,F., Zhao,D., Huang,P.T. and Huang,C.F. (1999) Conopeptides from Conus striatus and Conus textile by cDNA cloning Peptides 20:1139-1144
Dai,Q., Liu,F., Zhou,Y., Lu,B., Yu,F. and Huang,P. (2003) The synthesis of SO-3, a conopeptide with high analgesic activity derived from Conus striatus J. Nat. Prod. 66:1276-1279
Wen,L., Yang,S., Qiao,H., Liu,Z., Zhou,W., Zhang,Y. and Huang,P. (2005) SO-3, a new O-superfamily conopeptide derived from Conus striatus, selectively inhibits N-type calcium currents in cultured hippocampal neurons Br. J. Pharmacol. 145:728-739
Yan,Y.B., Tu,G.Z., Luo,X.C., Dai,Q.Y., Huang,P.T. and Zhang,R.Q. (2003) Three dimensional solution structure of omega-conotoxin SO3 determined by NMR Chin. Sci. Bull. 48:1097

Internal links
Nucleic acids Conus striatus omega conotoxin SO3 precursor (SO3) mRNA, complete cds
Structure

External links
UniProtKB/Swiss-Prot Q9XZK2
Ncbi Q9XZK2, AAD31908

Tools