GeXIVA[C2A,C27A] (P08691) Protein Card

General Information
Name GeXIVA[C2A,C27A]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[ribbon]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TARSSGRYCRSPYDRRRRYCRRITDAAV
Average Mass 3390.82
Monoisotopic Mass 3388.69
Isoelectric Point 12.80
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus1970 nM[1267-3068]Ach (10 uM)Xu et al. (2020)
α2β2R. norvegicus2990 nM[2702-33020]Ach (100 uM)Xu et al. (2020)
α3β2R. norvegicus1370 nM[740-2524]Ach (100 uM)Xu et al. (2020)
α3β4R. norvegicus6310 nM[4393-9076]Ach (100 uM)Xu et al. (2020)
α6/α3β4R. norvegicus6190 nM[4606-8319]Ach (100 uM)Xu et al. (2020)
α7R. norvegicus4580 nM[1895-11060]Ach (200 uM)Xu et al. (2020)
α9α10R. norvegicus17 nM[12-23]Ach (10 uM)Xu et al. (2020)

References
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S (2020) Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry

Internal links
Nucleic acids
Structure

External links

Tools