GeXIVA[C2S,C27S] (P08692) Protein Card

General Information
Name GeXIVA[C2S,C27S]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[ribbon]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TSRSSGRYCRSPYDRRRRYCRRITDASV
Average Mass 3422.82
Monoisotopic Mass 3420.68
Isoelectric Point 12.80
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus1450 nM[1090-1936]Ach (10 uM)Xu et al. (2020)
α2β2R. norvegicus2230 nM[957-5210]Ach (100 uM)Xu et al. (2020)
α3β2R. norvegicus1570 nM[847-2905]Ach (100 uM)Xu et al. (2020)
α3β4R. norvegicus7570 nM[3204-17890]Ach (100 uM)Xu et al. (2020)
α6/α3β4R. norvegicus4360 nM[3184-5972]Ach (100 uM)Xu et al. (2020)
α7R. norvegicus3020 nM[2139-4271]Ach (200 uM)Xu et al. (2020)
α9α10R. norvegicus21 nM[17-27]Ach (10 uM)Xu et al. (2020)

References
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S (2020) Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry

Internal links
Nucleic acids
Structure

External links

Tools