GeXIVA[C9A,C20A] (P08693) Protein Card

General Information
Name GeXIVA[C9A,C20A]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[ribbon]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TCRSSGRYARSPYDRRRRYARRITDACV
Average Mass 3390.82
Monoisotopic Mass 3388.69
Isoelectric Point 12.80
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus700 nM[457-1085]Ach (10 uM)Xu et al. (2020)
α2β2R. norvegicus3980 nM[1277-12390]Ach (100 uM)Xu et al. (2020)
α3β2R. norvegicus1050 nM[520-2103]Ach (100 uM)Xu et al. (2020)
α3β4R. norvegicus4750 nM[2256-10000]Ach (100 uM)Xu et al. (2020)
α6/α3β4R. norvegicus3780 nM[2684-5336]Ach (100 uM)Xu et al. (2020)
α7R. norvegicus3360 nM[2166-5202]Ach (200 uM)Xu et al. (2020)
α9α10R. norvegicus36 nM[30-43]Ach (10 uM)Xu et al. (2020)

References
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S (2020) Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry

Internal links
Nucleic acids
Structure

External links

Tools