GeXIVA[C9S,C20S] (P08694) Protein Card

General Information
Name GeXIVA[C9S,C20S]
Organism synthetic construct
Protein Type Synthetic
Parent GeXIVA[ribbon]

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family alpha conotoxin

Sequence
TCRSSGRYSRSPYDRRRRYSRRITDACV
Average Mass 3422.82
Monoisotopic Mass 3420.68
Isoelectric Point 12.80
Extinction Coefficient [280nm] 4470.00

Activity

IC50: Nicotinic acetylcholine receptors

TargetOrganismIC50AgonistRef
α1β1δεM. musculus2990 nM[2353-3808]Ach (10 uM)Xu et al. (2020)
α2β2R. norvegicus2160 nM[506-9187]Ach (100 uM)Xu et al. (2020)
α3β2R. norvegicus1180 nM[518-2683]Ach (100 uM)Xu et al. (2020)
α3β4R. norvegicus3660 nM[1926-6966]Ach (100 uM)Xu et al. (2020)
α6/α3β4R. norvegicus2100 nM[1285-3429]Ach (100 uM)Xu et al. (2020)
α7R. norvegicus1510 nM[916-2487]Ach (200 uM)Xu et al. (2020)
α9α10R. norvegicus13 nM[10-17]Ach (10 uM)Xu et al. (2020)

References
Xu, P., Kaas, Q., Wu, Y., Zhu, X., Li, X., Harvey, P.J., Zhangsun, D., Craik, D.J. and Luo, S (2020) Structure and Activity Studies of Disulfide-Deficient Analogues of αO-Conotoxin GeXIVA Journal of Medicinal Chemistry

Internal links
Nucleic acids
Structure

External links

Tools