Conorfamide-Sr3 (P08699) Protein Card

General Information
Name Conorfamide-Sr3 (named by ConoServer)
Alternative name(s) CNF-Sr3
Organism Conus spurius
Organism region Western Atlantic and Caribbean
Organism diet vermivorous
Protein Type Wild type
Notes López-Vera et al. (2020) reported that Conorfamide-Sr3 might become a novel molecular probe to study diverse aspects of human Kv1.3 and Kv1.6 channels.

Conopeptide class conorfamide
Gene superfamily
Pharmacological family

Modified residues
16nh2C-term amidation
Sequence evidence protein level
Average Mass 1728.05
Monoisotopic Mass 1726.86
Isoelectric Point 11.16
Extinction Coefficient [280nm] 6990.00


IC50: Voltage-Gated Potassium Channels

Kv1.3H. sapiens24 uM+/-42.1López-Vera,E. et al. (2020)
Kv1.6H. sapiens2.7 uM+/-0.91.08López-Vera,E. et al. (2020)

Kd: Voltage-Gated Potassium Channels

Kv ShakerD. melanogaster2.7 uM+/-0.35Campos-Lira et al. (2017)

Percentage inhibition: Voltage-Gated Potassium Channels

TargetOrganism% inhibitionConcentrationRef
Kv1.3H. sapiens20+/-2.510 uMLópez-Vera,E. et al. (2020)
10030 uMLópez-Vera,E. et al. (2020)
Kv1.4H. sapiens< 510 uMLópez-Vera,E. et al. (2020)
Kv1.5H. sapiens< 510 uMLópez-Vera,E. et al. (2020)
Kv1.6H. sapiens10030 uMLópez-Vera,E. et al. (2020)
80+/-5.010 uMLópez-Vera,E. et al. (2020)

Campos-Lira, E., Carrillo, E., Aguilar, M.B., Gajewiak, J., Gómez-Lagunas, F. and López-Vera, E (2017) Conorfamide-Sr3, a structurally novel specific inhibitor of the Shaker K+ channel Toxicon 138:53-58
López-Vera,E., Martínez-Hernández,L., Aguilar,M.B., Carrillo,E. and Gajewiak,J. (2020) Studies of Conorfamide-Sr3 on Human Voltage-Gated Kv1 Potassium Channel Subtypes. Mar Drugs 18

Internal links
Nucleic acids

External links
UniProtKB/Swiss-Prot P0DM28
Ncbi P0DM28