MrIA [insN_ILRGILR,del 6-13] (P08712) Protein Card

General Information
Name MrIA [insN_ILRGILR,del 6-13] (named by ConoServer)
Organism synthetic construct
Protein Type Synthetic
Parent MrIA

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family

Sequence
ILRGILRNGVCC(nh2)
Modified residues
positionsymbolname
13nh2C-term amidation
Sequence evidence protein level
Average Mass 1313.65
Monoisotopic Mass 1312.72
Isoelectric Point 12.50
Extinction Coefficient [280nm] NA

Activity

IC50: Monoamine transporter

TargetOrganismIC50Ref
NETH. sapiens(IC50 calculated from reported pIC50)32 uMZiegman et al. (2019)

References
Ziegman, R., Brust, A., Jha, P., Cardoso, F.C., Lewis, R.J. and Alewood, P.F. (2019) ‘Messy’Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency Marine drugs 17:165

Internal links
Nucleic acids
Structure

External links

Tools