Asi14.1 (P08781) Protein Card

General Information
Name Asi14.1 (named by ConoServer)
Alternative name(s) Asi14a
Organism Conus asiaticus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Notes Lebbe et al 2016 reported that no activity of Asi14a against 29 Gram-negative, 10 Gram-positive bacterial strains and two yeast strains.

Conopeptide class conotoxin
Gene superfamily
Cysteine framework XIV
Pharmacological family

Modified residues
18nh2C-term amidation
Sequence evidence protein level
Average Mass 1695.91
Monoisotopic Mass 1694.61
Isoelectric Point 8.15
Extinction Coefficient [280nm] 2980.00


Percentage inhibition: Voltage-Gated Potassium Channels

TargetOrganism% inhibitionConcentrationRef
Kv1.1R. norvegicus010 µMLebbe,E.K. et al. (2016)
Kv1.2R. norvegicus010 µMLebbe,E.K. et al. (2016)
Kv1.3H. sapiens010 µMLebbe,E.K. et al. (2016)
Kv1.4R. norvegicus010 µMLebbe,E.K. et al. (2016)
Kv1.5R. norvegicus010 µMLebbe,E.K. et al. (2016)
Kv1.6R. norvegicus010 µMLebbe,E.K. et al. (2016)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α1β1δεR. norvegicus05 µMLebbe,E.K. et al. (2016)
α3β4H. sapiens05 µMLebbe,E.K. et al. (2016)
α4β4H. sapiens05 µMLebbe,E.K. et al. (2016)
α7G. gallus05 µMLebbe,E.K. et al. (2016)

Lebbe,E.K., Ghequire,M.G., Peigneur,S., Mille,B.G., Devi,P., Ravichandran,S., Waelkens,E., D Souza,L., De Mot,R. and Tytgat,J. (2016) Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs 14

Internal links
Nucleic acids

External links