Asi3.1 (P08782) Protein Card

General Information
Name Asi3.1 (named by ConoServer)
Alternative name(s) Asi3a
Organism Conus asiaticus
Organism region Indo-Pacific
Organism diet vermivorous
Protein Type Wild type
Notes Lebbe et al., 2016 reported that no activity of Asi3.1 against 29 Gram-negative and 10 Gram-positive bacterial strains and two yeast strains.

Conopeptide class conotoxin
Gene superfamily
Cysteine framework III
Pharmacological family

Modified residues
16nh2C-term amidation
Sequence evidence protein level
Average Mass 1695.99
Monoisotopic Mass 1694.54
Isoelectric Point 8.75
Extinction Coefficient [280nm] 6990.00


Percentage inhibition: Voltage-Gated Potassium Channels

TargetOrganism% inhibitionConcentrationRef
Kv1.1R. norvegicus010 uMLebbe,E.K. et al. (2016)
Kv1.2R. norvegicus010 uMLebbe,E.K. et al. (2016)
Kv1.3H. sapiens010 uMLebbe,E.K. et al. (2016)
Kv1.4R. norvegicus010 uMLebbe,E.K. et al. (2016)
Kv1.5R. norvegicus010 uMLebbe,E.K. et al. (2016)
Kv1.6R. norvegicus010 uMLebbe,E.K. et al. (2016)

Percentage inhibition: Voltage-Gated Sodium Channels

TargetOrganism% inhibitionConcentrationRef
Nav1.1R. norvegicus010 uMLebbe,E.K. et al. (2016)
Nav1.2R. norvegicus010 uMLebbe,E.K. et al. (2016)
Nav1.3R. norvegicus010 uMLebbe,E.K. et al. (2016)
Nav1.4R. norvegicus010 uMLebbe,E.K. et al. (2016)
Nav1.5H. sapiens010 uMLebbe,E.K. et al. (2016)
Nav1.6M. musculus010 uMLebbe,E.K. et al. (2016)
Nav1.8H. sapiens010 uMLebbe,E.K. et al. (2016)

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationRef
α1β1δεR. norvegicus05 uMLebbe,E.K. et al. (2016)
α3β4H. sapiens05 uMLebbe,E.K. et al. (2016)
α4β4H. sapiens05 uMLebbe,E.K. et al. (2016)
α7G. gallus05 uMLebbe,E.K. et al. (2016)

Lebbe,E.K., Ghequire,M.G., Peigneur,S., Mille,B.G., Devi,P., Ravichandran,S., Waelkens,E., D Souza,L., De Mot,R. and Tytgat,J. (2016) Novel Conopeptides of Largely Unexplored Indo Pacific Conus sp. Mar Drugs 14

Internal links
Nucleic acids

External links