GVIIJ[(Btr)2W,T9A,(Scc)24(Eac)] (P08800) Protein Card

General Information
Name GVIIJ[(Btr)2W,T9A,(Scc)24(Eac)] (named by ConoServer)
Alternative name(s) [T9A]GVIIJ[SSEA]
Organism synthetic construct
Protein Type Synthetic
Parent GVIIJ

Classification
Conopeptide class conotoxin
Gene superfamily
Cysteine framework VI/VII
Pharmacological family mu conotoxin

Sequence
GWCGDOGAACGKLRLYCCSGFCD(Eac)YTKTCKDKSSA
Modified residues
positionsymbolname
6O4-Hydroxyproline
24Eac2-aminoethanethiol (cysteamine) cysteine
Sequence evidence protein level
Average Mass 3785.33
Monoisotopic Mass 3782.51
Isoelectric Point 10.68
Extinction Coefficient [280nm] 8480.00

Activity

Kd: Voltage-Gated Sodium Channels

TargetOrganismKdRef
Nav1.2R. norvegicus1.20 nM+/-0.7Green,B.R. et al. (2016)

References
Green,B.R., Gajewiak,J., Chhabra,S., Skalicky,J.J., Zhang,M.M., Rivier,J.E., Bulaj,G., Olivera,B.M., Yoshikami,D. and Norton,R.S. (2016) Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem. 291:7205-7220

Internal links
Nucleic acids
Structure

External links

Tools