GVIIJ[(Btr)2W,(Scc)24(Eac),Y25A] (P08810) Protein Card

General Information

Name	GVIIJ[(Btr)2W,(Scc)24(Eac),Y25A] (named by ConoServer)
Alternative name(s)	[Y25A]GVIIJ[SSEA]
Organism	synthetic construct
Protein Type	Synthetic
Parent	GVIIJ

Classification

Conopeptide class	conotoxin
Gene superfamily
Cysteine framework	VI/VII
Pharmacological family	mu conotoxin

Sequence

GWCGDOGATCGKLRLYCCSGFCD(Eac)ATKTCKDKSSA
Modified residues	position symbol name 6 O 4-Hydroxyproline 24 Eac 2-aminoethanethiol (cysteamine) cysteine
Sequence evidence	protein level
Average Mass	3723.25
Monoisotopic Mass	3720.49
Isoelectric Point	10.68
Extinction Coefficient [280nm]	6990.00

Activity

Kd: Voltage-Gated Sodium Channels

Target	Organism	Kd		Ref
Nav1.2	R. norvegicus	8.30 nM	+/-5.7	Green,B.R. et al. (2016)

References

Green,B.R., Gajewiak,J., Chhabra,S., Skalicky,J.J., Zhang,M.M., Rivier,J.E., Bulaj,G., Olivera,B.M., Yoshikami,D. and Norton,R.S. (2016) Structural Basis for the Inhibition of Voltage-gated Sodium Channels by Conotoxin μO§-GVIIJ. J. Biol. Chem. 291:7205-7220

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 28 March 2023