Conorphin-T[globular] (P08845) Protein Card

General Information

Name	Conorphin-T[globular] (named by ConoServer)
Alternative name(s)	1(1-3,2-4)
Organism	Conus textile (Cloth-of-gold cone)
Organism region	Indo-Pacific
Organism diet	molluscivorous
Protein Type	Wild type
Protein precursor	Conorphin-T precursor (646) Conorphin-T precursor (6097) Conorphin-T precursor (1678)

Classification

Conopeptide class	conorphin
Gene superfamily	T superfamily
Cysteine framework	V
Pharmacological family

Sequence

NCCRRQICC(nh2)
Modified residues	position symbol name 10 nh2 C-term amidation
Sequence evidence	protein level
Average Mass	1093.32
Monoisotopic Mass	1092.42
Isoelectric Point	12.50
Extinction Coefficient [280nm]	NA

Activity

Ki: Opioid receptors

Target	Organism	Ki		Competitor	Agonist	Ref
κ	synthetic construct	1474 nM	+/-1965			Brust,A. et al. (2016)

References

Brust,A., Croker,D.E., Colless,B., Ragnarsson,L., Andersson,A., Jain,K., Garcia-Caraballo,S., Castro,J., Brierley,S.M., Alewood,P.F., Lewis,R.J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J Med Chem

Internal links

Protein Precursor	Conorphin-T precursor (646) Conorphin-T precursor (6097) Conorphin-T precursor (1678)
Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Sunday 28 May 2023