Conorphin-T[N1(BzP),del2-3,R4r,R5r,I7(Cha),C8(Nmc)] (P08860) Protein Card

General Information
Name Conorphin-T[N1(BzP),del2-3,R4r,R5r,I7(Cha),C8(Nmc)] (named by ConoServer)
Alternative name(s) Brust46
Organism synthetic construct
Protein Type Synthetic
Parent Conorphin-T[ribbon]

Classification
Conopeptide class conorphin
Gene superfamily
Pharmacological family

Sequence
(Bnz)PrrQ(Cha)(Nmc)C(nh2)
Modified residues
positionsymbolname
1BnzN-term benzoyl
3rD-arginine
4rD-arginine
6ChaCyclohexylalanine
7NmcN-methyl (half) cystine
9nh2C-term amidation
Sequence evidence protein level
Average Mass 1031.28
Monoisotopic Mass 1030.51
Isoelectric Point NA
Extinction Coefficient [280nm] NA

Activity

Ki: Opioid receptors

TargetOrganismKiCompetitorAgonistRef
κsynthetic construct15.2 nM+/-8.8Brust,A. et al. (2016)

References
Brust,A., Croker,D.E., Colless,B., Ragnarsson,L., Andersson,A., Jain,K., Garcia-Caraballo,S., Castro,J., Brierley,S.M., Alewood,P.F., Lewis,R.J. (2016) Conopeptide-Derived κ-Opioid Agonists (Conorphins): Potent, Selective, and Metabolic Stable Dynorphin A Mimetics with Antinociceptive Properties J Med Chem

Internal links
Nucleic acids
Structure

External links

Tools