Czon1107[P7A] (P08895) Protein Card

General Information

Name	Czon1107[P7A]
Organism	synthetic construct
Protein Type	Synthetic
Parent	Czon1107

Classification

Conopeptide class	conotoxin
Gene superfamily
Pharmacological family

Sequence

GFRSPCAPFC(nh2)

Modified residues

position	symbol	name
11	nh2	C-term amidation

Sequence evidence

protein level

Average Mass

1081.27

Monoisotopic Mass

1080.46

Isoelectric Point

11.16

Extinction Coefficient [280nm]

Activity

IC50: Nicotinic acetylcholine receptors

Target	Organism	IC50		Agonist	Ref
α3β4	H. sapiens	>100		Ach (100 uM)	Mohan,M.K. et al. (2020)
α7	H. sapiens	26.2	+/-6	Ach (100 uM)	Mohan,M.K. et al. (2020)

References

Mohan,M.K., Abraham,N., R P,R., Jayaseelan,B.F., Ragnarsson,L., Lewis,R.J. and Sarma,S.P (2020) Structure and allosteric activity of a single-disulfide conopeptide from Conus zonatus at human α3β4 and α7 nicotinic acetylcholine receptors J. Biol. Chem. 295:7096-7112

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 28 March 2023