TxIB[insN_GAAG] cyclic (P08898) Protein Card

General Information

Name	TxIB[insN_GAAG] cyclic (named by ConoServer)
Alternative name(s)	cTxIB-4
Organism	synthetic construct
Protein Type	Synthetic
Parent	TxIB

Classification

Conopeptide class	conotoxin
Gene superfamily
Pharmacological family

Sequence

GAAGGCCSDPPCRNKHPDLC
Sequence evidence	protein level
Average Mass	1997.22
Monoisotopic Mass	1995.78
Isoelectric Point	8.31
Extinction Coefficient [280nm]	NA

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

Target	Organism	% inhibition		Concentration	Agonist	Ref
α6β2β3	M. musculus	35		100 nM	Ach (100 uM)	Li,X. et al. (2020)

References

Li,X., Wang,S., Zhu,X., Zhangsun,D., Wu,Y. and Luo,S (2020) Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB Mar Drugs 18

Internal links

Nucleic acids
Structure

External links

Tools

Please cite:
Kaas Q, Yu R, Jin AH, Dutertre S and Craik DJ. ConoServer: updated content, knowledge, and discovery tools in the conopeptide database. Nucleic Acids Research (2012) 40(Database issue):D325-30
Kaas Q, Westermann JC, Halai R, Wang CK and Craik DJ. ConoServer, a database for conopeptide sequences and structures. Bioinformatics (2008) 24(3):445-6

ConoServer is managed at the Institute of Molecular Bioscience IMB, Brisbane, Australia.

The database and computational tools found on this website may be used for academic research only, provided that it is referred to ConoServer, the database of conotoxins (http://www.conoserver.org) and the above reference is cited. For any other use please contact David Craik (d.craik@imb.uq.edu.au).

Contacts:
David Craik
Quentin Kaas

Last updated: Tuesday 21 March 2023