TxIB[insN_GGAAGAG] cyclic (P08901) Protein Card

General Information
Name TxIB[insN_GGAAGAG] cyclic (named by ConoServer)
Alternative name(s) cTxIB-7
Organism synthetic construct
Protein Type Synthetic
Parent TxIB
Notes Li et al.,2020 reported that TxIB[insN_GGAAGAG] cyclic had significantly better stability than the native peptide TxIB as approximately 50% of cTxIB-7 remained after incubation in human serum for 48 h at 37 â—¦C whereas only 20% of TxIB remains in similar conditions.

Classification
Conopeptide class conotoxin
Gene superfamily
Pharmacological family

Sequence
GGAAGAGGCCSDPPCRNKHPDLC
Sequence evidence protein level
Average Mass 2182.40
Monoisotopic Mass 2180.86
Isoelectric Point 8.31
Extinction Coefficient [280nm] NA

Activity

Percentage inhibition: Nicotinic acetylcholine receptors

TargetOrganism% inhibitionConcentrationAgonistRef
α6/α3β2β3R. norvegicus41100 nMAch (100 uM)Li,X. et al. (2020)

References
Li,X., Wang,S., Zhu,X., Zhangsun,D., Wu,Y. and Luo,S (2020) Effects of Cyclization on Activity and Stability of α-Conotoxin TxIB Mar Drugs 18

Internal links
Nucleic acids
Structure

External links

Tools