conomarphin-Ac1 (P08909) Protein Card

General Information
Name conomarphin-Ac1 (named by ConoServer)
Alternative name(s) conotoxin-Ac1,Ac3.1
Organism Conus achatinus
Organism region Indo-Pacific
Organism diet piscivorous
Protein Type Wild type
Protein precursor conomarphin-Ac1 precursor (4216)
Notes Liu et al., 2020 reported that N1, Y2, Y3, E10, N11, S12, and T15 play an important role in the analgesic activity of conomarphin-Ac1. The inhibition of 10 μM conomarphin-Ac1 to NaV,Kv,CaV,NMDAR is 0.55%,5.50%,6.70% and 56.90% respectively.

Classification
Conopeptide class conomarphin
Gene superfamily M superfamily
Pharmacological family

Sequence
NYYLYOAROENSwwT
Modified residues
positionsymbolname
6O4-Hydroxyproline
9O4-Hydroxyproline
13wD-tryptophan
14wD-tryptophan
Sequence evidence protein level
Average Mass 1992.14
Monoisotopic Mass 1990.88
Isoelectric Point 7.88
Extinction Coefficient [280nm] 15470.00

Activity

Percentage inhibition: Ionotropic glutamate receptors

TargetOrganism% inhibitionConcentrationRef
GluN2AH. sapiens710 uMLiu,X. et al. (2020)
GluN2BH. sapiens52+/-810 uMLiu,X. et al. (2020)

Synthetic variants
conomarphin-Ac1 amidatedNYYLYOAROENSwwT(nh2)
conomarphin-Ac1[E10(Gla), W14(Gla)]NYYLYOARO(Gla)NSw(Gla)T
conomarphin-Ac1[E10(Gla), W14(Gla)] amidatedNYYLYOARO(Gla)NSw(Gla)T(nh2)
conomarphin-Ac1[E10(Gla)]NYYLYOARO(Gla)NSwwT
conomarphin-Ac1[E10A]NYYLYOAROANSwwT
conomarphin-Ac1[L4A]NYYAYOAROENSwwT
conomarphin-Ac1[N11A]NYYLYOAROEASwwT
conomarphin-Ac1[N1A]AYYLYOAROENSwwT
conomarphin-Ac1[O6A]NYYLYAAROENSwwT
conomarphin-Ac1[O9A]NYYLYOARAENSwwT
conomarphin-Ac1[R8A]NYYLYOAAOENSwwT
conomarphin-Ac1[S12A]NYYLYOAROENAwwT
conomarphin-Ac1[T15A]NYYLYOAROENSwwA
conomarphin-Ac1[W13A]NYYLYOAROENSAwT
conomarphin-Ac1[W14A]NYYLYOAROENSwAT
conomarphin-Ac1[Y2A]NAYLYOAROENSwwT
conomarphin-Ac1[Y3A]NYALYOAROENSwwT
conomarphin-Ac1[Y5A]NYYLAOAROENSwwT

References
Liu,X., Yao,G., Wang,K., Liu,Y., Wan,X. and Jiang,H (2020) Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR Marine drugs 18

Internal links
Protein Precursor conomarphin-Ac1 precursor (4216)
Nucleic acids
Structure

External links

Tools