conomarphin-Ac1[W14A] (P08922) Protein Card

General Information
Name conomarphin-Ac1[W14A] (named by ConoServer)
Alternative name(s) conotoxin-Ac1-W14A
Organism synthetic construct
Protein Type Synthetic
Parent conomarphin-Ac1

Classification
Conopeptide class conomarphin
Gene superfamily
Pharmacological family

Sequence
NYYLYOAROENSwAT
Modified residues
positionsymbolname
6O4-Hydroxyproline
9O4-Hydroxyproline
13wD-tryptophan
Sequence evidence protein level
Average Mass 1877.00
Monoisotopic Mass 1875.84
Isoelectric Point 7.88
Extinction Coefficient [280nm] 9970.00

Activity

Percentage inhibition: Ionotropic glutamate receptors

TargetOrganism% inhibitionConcentrationRef
GluN2BH. sapiens16+/-110 uMLiu,X. et al. (2020)

References
Liu,X., Yao,G., Wang,K., Liu,Y., Wan,X. and Jiang,H (2020) Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR Marine drugs 18

Internal links
Nucleic acids
Structure

External links

Tools