conomarphin-Ac1[E10(Gla)] (P08924) Protein Card

General Information
Name conomarphin-Ac1[E10(Gla)] (named by ConoServer)
Alternative name(s) conotoxin-Ac1-E10γ
Organism synthetic construct
Protein Type Synthetic
Parent conomarphin-Ac1

Classification
Conopeptide class conomarphin
Gene superfamily
Pharmacological family

Sequence
NYYLYOARO(Gla)NSwwT
Modified residues
positionsymbolname
6O4-Hydroxyproline
9O4-Hydroxyproline
10GlaGamma carboxylic glutamic acid
13wD-tryptophan
14wD-tryptophan
Sequence evidence protein level
Average Mass 2036.15
Monoisotopic Mass 2034.87
Isoelectric Point 7.88
Extinction Coefficient [280nm] 15470.00

Activity

Percentage inhibition: Ionotropic glutamate receptors

TargetOrganism% inhibitionConcentrationRef
GluN2BH. sapiens4+/-210 uMLiu,X. et al. (2020)

References
Liu,X., Yao,G., Wang,K., Liu,Y., Wan,X. and Jiang,H (2020) Structural and Functional Characterization of Conotoxins from Conus achatinus Targeting NMDAR Marine drugs 18

Internal links
Nucleic acids
Structure

External links

Tools